Cinchonine

CAT: 0804-HY-Y0152-01Size: 5 gDry Ice: NoHazardous: No
CAT#:0804-HY-Y0152-01Size:5 g
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1].
CAS Number
[118-10-5]
Product Name Alternative
(8R,9S) -Cinchonine; LA40221
UNSPSC
12352005
Hazard Statement
H302, H317, H402
Target
Apoptosis; Autophagy; Calcium Channel; Caspase; Parasite
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Others
Assay Protocol
https://www.medchemexpress.com/Cinchonine.html
Purity
99.71
Solubility
DMSO : 4.76 mg/mL (ultrasonic)
Smiles
O[C@@H](C1=CC=NC2=CC=CC=C12)[C@]3([H])[N@@]4C[C@H](C=C)[C@@H](CC4)C3
Molecular Formula
C19H22N2O
Molecular Weight
294.40
Precautions
H302, H317, H402
References & Citations
[3]Jin ZL, et al., Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15 (6) :5046-5050.|[4]Wang H, et al., Cinchonine exerts anti-tumor and immunotherapy sensitizing effects in lung cancer by impairing autophagic-lysosomal degradation. Biomed Pharmacother. 2023 Aug;164:114980.|[5]Jung SA, et al., Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation. PPAR Res. 2012;2012:541204.|[6]Jo YJ, et al., Cinchonine inhibits osteoclast differentiation by regulating TAK1 and AKT, and promotes osteogenesis. J Cell Physiol. 2021 Mar;236 (3) :1854-1865.|[7]Shah BH, et al., The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx. Biochem Pharmacol. 1998 Oct 15;56 (8) :955-60.|[8]Rani R, et al., Intracellular ROS production and apoptotic effect of quinoline and isoquinoline alkaloids on the growth of Trypanosoma evansi. Acta Trop. 2023 Sep;245:106980.|[1]Jin ZL, et al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15 (6) :5046-5050.|[2]Qi Y, et al., Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6. J Exp Clin Cancer Res. 2017 Feb 23;36 (1) :35.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Related Products

CatalogName
HY-N0173-01Cinchonidine
HY-N13692Cinchonain Ia
HY-N0173R-01Cinchonidine (Standard)
HY-N7709Cinchonain IIb
HY-133965Cinchonain IIa
HY-N9763Cinchonain Ib
HY-W035708R(8α,9R) -10,11-dihydro-Cinchonan-9-ol (Standard)

Alternative Products

CatalogName
GK1431-250gCinchonine
300081Cinchonine hydrochloride
sc-268719(+) -Cinchonine monohydrochloride
C6446-25Cinchonine(LA40221)
MBS3842225-01Cinchonine (LA40221)
053435-01Cinchonine for Synthesis
C22390-01(+) -Cinchonine 98%
TRC-C441943-25GCinchonine Hemisulfate Salt
A17250-5000Cinchonine (LA40221) 5g
MF-0138719-01Cinchonine monohydrochloride hydrate

Popular Products