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Sembragiline

CAT: 0804-HY-16731-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16731-01Size:1 mg
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Description
Sembragiline (EVT 302) is a potent, selective and reversible monoamine oxidase B (MAO-B) inhibitor. Sembragiline reduces the metabolism of dopamine and other amine neurotransmitters by inhibiting the activity of the MAO-B enzyme, thereby potentially increasing the concentration of these neurotransmitters in the brain. Inhibition of the MAO-B enzyme also reduces the formation of toxic reactive oxygen species (ROS) that play a role in the pathological process of AD. Sembragiline has good oral activity and blood-brain barrier permeability. Sembragiline can be used in studies of AD, especially in patients with AD who show increased MAO-B activity[1].
CAS Number
676479-06-4
Product Name Alternative
EVT 302; RG1577; RO4602522
UNSPSC
12352005
Target
Monoamine Oxidase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sembragiline.html
Smiles
CC(N[C@@H](C1)CN(C2=CC=C(OCC3=CC=CC(F)=C3)C=C2)C1=O)=O
Molecular Formula
C19H19FN2O3
Molecular Weight
342.36
References & Citations
[1]Sturm S, et al. Positron emission tomography measurement of brain MAO-B inhibition in patients with Alzheimer’s disease and elderly controls after oral administration of sembragiline[J]. European journal of nuclear medicine and molecular imaging, 2017, 44: 382-391.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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