Products for Research Use Only
RegisterLogin

GSK180736A

CAT: 0804-HY-18990-01Size: 2 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-18990-01Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GSK180736A is potent Rho-associated coiled-coil kinase 1 (ROCK1) inhibitor with an IC50 of 100 nM. GSK180736A is also a selective and ATP-competitive G protein-coupled receptor kinase 2 (GRK2) inhibitor with an IC50 of 0.77 μM.
CAS Number
817194-38-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
G Protein-coupled Receptor Kinase (GRK) ; ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/GSK180736A.html
Purity
98.81
Solubility
DMSO : ≥ 30 mg/mL
Smiles
CC(N1)=C(C(NC2=CC=C(NN=C3)C3=C2)=O)C(C4=CC=C(F)C=C4)NC1=O
Molecular Formula
C19H16FN5O2
Molecular Weight
365.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Waldschmidt HV, et al. Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem. 2016 Apr 28;59 (8) :3793-807.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GRK2; ROCK1

Alternative Products

CatalogName
BA4483-5.1GSK180736A
S8489-10mgGSK180736A (GSK180736)
A20736-500GSK180736A 500mg
A20736-100GSK180736A 100mg
A20736-25GSK180736A 25mg
A20736-10GSK180736A 10mg
A20736-50GSK180736A 50mg
A20736-5GSK180736A 5mg
A20736-2GSK180736A 2mg
A20736-1GSK180736A 1mg

Popular Products