Enpp-1-IN-20

Enpp-1-IN-20

• UNSPSC Description: Enpp-1-IN-20 (Compound 31) is an ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitor, with an IC50 of 0.09 nM. Enpp-1-IN-20 has strongest inhibitory activity in the cell-based assay, with an IC50 of 8.8 nM. Enpp-1-IN-20 has significant potency in both ENPP1 inhibition and STING pathway stimulation in vitro. Enpp-1-IN-20 can be used for the research of cancer[1].
• Target Antigen: Phosphodiesterase (PDE); STING
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/enpp-1-in-20.html
• Solubility: DMSO : 1.92 mg/mL (ultrasonic;adjust pH to 2 with 1 M HCL)
• Smiles: O=C1NC(N=CN=C2N3C[C@@]4([C@]([H])(C3)[C@H]4CCP(O)(O)=O)[H])=C2C=C1
• Molecular Weight: 336.28
• References & Citations: [1]Sun Y, et al. Discovery of Pyrido[2,3-d]pyrimidin-7-one Derivatives as Highly Potent and Efficacious Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Cancer Treatment. J Med Chem. 2024 Feb 22.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported