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Apimostinel

CAT: 0804-HY-102053-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-102053-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Apimostinel (NRX-1074; AGN-241660) is an orally active NMDA receptor partial agonist[1].
CAS Number
1421866-48-9
Product Name Alternative
NRX-1074; AGN-241660
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Apimostinel.html
Purity
99.04
Solubility
DMSO : 155 mg/mL (ultrasonic) |H2O : ≥ 6.67 mg/mL
Smiles
C[C@@H](O)[C@@H](C(N)=O)NC([C@@]1(CC2=CC=CC=C2)N(C([C@H]3N(C([C@H]([C@H](O)C)N)=O)CCC3)=O)CCC1)=O
Molecular Formula
C25H37N5O6
Molecular Weight
503.59
References & Citations
[1]Naurex's First Orally Active Molecule, NRX-1074, Demonstrates Statistically Significant Improvement in Depression Scores within 24 Hours in Phase 2 Study for Major Depressive Disorder. January 28, 2015.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NMDA Receptor

Chemical Information

Apimostinel

NRX-1074 has been used in trials studying the treatment of Schizophrenia.

CAS Number1421866-48-9
PubChem CID71249967
IUPAC Name(2R)-1-[(2S)-1-[(2S,3R)-2-amino-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]-N-[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]-2-benzylpyrrolidine-2-carboxamide
Molecular FormulaC25H37N5O6
Molecular Weight503.6
XLogP-1
Topological Polar Surface Area179
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Heavy Atom Count36
Formal Charge0
Complexity834
SMILES
C[C@H]([C@@H](C(=O)N1CCC[C@H]1C(=O)N2CCC[C@@]2(CC3=CC=CC=C3)C(=O)N[C@@H]([C@@H](C)O)C(=O)N)N)O
InChI
InChI=1S/C25H37N5O6/c1-15(31)19(26)23(35)29-12-6-10-18(29)22(34)30-13-7-11-25(30,14-17-8-4-3-5-9-17)24(36)28-20(16(2)32)21(27)33/h3-5,8-9,15-16,18-20,31-32H,6-7,10-14,26H2,1-2H3,(H2,27,33)(H,28,36)/t15-,16-,18+,19+,20+,25-/m1/s1
InChIKey
DVBUEXCIEIAXPM-PJUQSVSOSA-N
Chemical Structure
2D Structure
2D structure of Apimostinel
CAS: 1421866-48-9
CID: 71249967
Formula: C25H37N5O6
MW: 503.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight503.6
XLogP3-1
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count7
Rotatable Bond Count9
Exact Mass503.27438392
Monoisotopic Mass503.27438392
Topological Polar Surface Area179 Ų
Heavy Atom Count36
Formal Charge0
Complexity834
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T14306-01Apimostinel
A20075-100Apimostinel 100mg
A20075-5Apimostinel 5mg
A20075-10Apimostinel 10mg
A20075-50Apimostinel 50mg
A20075-25Apimostinel 25mg

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