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VU0431316

CAT: 0804-HY-12371Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12371Size:1 Each
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Description
VU0431316 is a potent and selective non-competitive antagonist of mGlu5 with an IC50 value of 24 nM[1].
CAS Number
1620203-63-5
UNSPSC
12352005
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0431316.html
Smiles
O=C(C1=NC=CC(Cl)=C1)NC2=NC(OC3=CN=CN=C3)=CN=C2
Molecular Formula
C14H9ClN6O2
Molecular Weight
328.71
References & Citations
[1]Brittney S Bates, et al. Discovery of VU0431316: a negative allosteric modulator of mGlu5 with activity in a mouse model of anxiety. Bioorg Med Chem Lett. 2014 Aug 1;24 (15) :3307-14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T24947-01VU0431316

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