Selexipag

• Description :

  Selexipag (NS-304) is an orally available and potent agonist for the Prostacyclin (PGI2) receptor (IP receptor) .

• CAS Number :

  [475086-01-2]

• Product Name Alternative :

  NS-304; ACT-293987

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Prostaglandin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cardiovascular Disease; Endocrinology

• Assay Protocol :

  https://www.medchemexpress.com/NS-304.html

• Concentration :

  10mM

• Purity :

  99.86

• Solubility :

  DMSO : ≥ 50 mg/mL

• Smiles :

  O=C(NS(=O)(C)=O)COCCCCN(C1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)N=C1)C(C)C

• Molecular Formula :

  C26H32N4O4S

• Molecular Weight :

  496.62

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kuwano K, et al. 2-[4-[ (5,6-diphenylpyrazin-2-yl) (isopropyl) amino]butoxy]-N- (methylsulfonyl) acetamide (NS-304), an orally available and long-acting prostacyclin receptor agonist prodrug. J Pharmacol Exp Ther. 2007 Sep;322 (3) :1181-8.|[2]Mous DS, et al. Treatment of rat congenital diaphragmatic hernia with sildenafil and NS-304, selexipag's active compound, at the pseudoglandular stage improves lung vasculature. Am J Physiol Lung Cell Mol Physiol. 2018 May 10.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  IP