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DB008

CAT: 0804-HY-150221-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-150221-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DB008 is potent and selective PARP16 inhibitor with an IC50 value of 0.27 μM, containing an acrylamide electrophilic reagent. DB008 is membrane-permeable and marks PARP16 selectively[1]. DB008 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
2991637-98-8
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/db008.html
Concentration
10mM
Purity
98.47
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NN=C(CC2=CC=C(F)C(C(N3CCN(C(C=C)=O)CC3)=O)=C2)C4=C1C=CC(C#C)=C4
Molecular Formula
C25H21FN4O3
Molecular Weight
444.46
References & Citations
[1]Bejan DS, et, al. Structure-guided design and characterization of a clickable, covalent PARP16 inhibitor. Chem Sci. 2022 Nov 16;13 (46) :13898-13906.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP16

Alternative Products

CatalogName
T73542-01DB008

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