Products for Research Use Only
RegisterLogin

Osthenol

CAT: 0804-HY-N2554-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-N2554-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Osthenol (Ostenol) is a reversible, selective, competitive inhibitor of hMAO-A (IC50=0.74 μM, Ki=0.26 μM), with antifungal and antibacterial activity. Osthenol inhibits the oxidative deamination of hMAO-A and regulates the metabolism of monoamine neurotransmitters. Osthenol also inhibits the PI3K/AKT signaling pathway to induce apoptosis of colon cancer cells, arrest the cell cycle at the G1 phase, and inhibit cell proliferation. Osthenol is mainly used in the study of neurological diseases and cancer, especially depression-related MAO-A targeted intervention and colon cancer[1][2][3][4].
CAS Number
484-14-0
Product Name Alternative
Ostenol
UNSPSC
12352005
Target
Akt; Apoptosis; Monoamine Oxidase; PI3K
Type
Natural Products
Related Pathways
Apoptosis; Neuronal Signaling; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/osthenol.html
Purity
99.11
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=CC2=CC=C(O)C(C/C=C(C)\C)=C2O1
Molecular Formula
C14H14O3
Molecular Weight
230.26
References & Citations
[1]Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019 Mar 15;29 (6) :839-843.|[2]Zhuang B, et al. Osthenol inhibits the viability of HCT116 cells through suppressing PI3K/AKT signaling pathway. Int J Clin Exp Pathol, 2017, 10 (6) : 6308-6315.|[3]Nemolochnova AG, et al. Stability Study, Quantification Method and Pharmacokinetics Investigation of a Coumarin-Monoterpene Conjugate Possessing Antiviral Properties against Respiratory Syncytial Virus. Pharmaceuticals (Basel) . 2022 Sep 18;15 (9) :1158.|[4]Cho P, et al. Characterization of osthenol metabolism in vivo and its pharmacokinetics. Xenobiotica. 2020 Jul;50 (7) :839-846.|[5]Montagner C, et al. Antifungal activity of coumarins. Z Naturforsch C J Biosci. 2008 Jan-Feb;63 (1-2) :21-8.|[6]de Souza SM, et al. Antibacterial activity of coumarins. Z Naturforsch C J Biosci. 2005 Sep-Oct;60 (9-10) :693-700.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
MAO-A

Related Products

CatalogName
HY-N7037Osthol hydrate

Alternative Products

CatalogName
OR1023269-01Osthenol

Popular Products