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VU0467154

CAT: 0804-HY-112209-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112209-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU0467154 is a positive allosteric modulator of the M4 muscarinic acetylcholine receptor (mAChR), potentiating the response to ACh with pEC50s of 7.75, 6.2 and 6 for rat, human and cynomolgus monkey M4 receptor, respectively.
CAS Number
1451993-15-9
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
MAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/VU0467154.html
Purity
99.24
Solubility
DMSO : 13.89 mg/mL (ultrasonic)
Smiles
O=C(C1=C(N)C2=C(C)C(C)=NN=C2S1)NCC3=CC=C(S(=O)(C(F)(F)F)=O)C=C3
Molecular Formula
C17H15F3N4O3S2
Molecular Weight
444.45
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Bubser M, et al. Selective activation of M4 muscarinic acetylcholine receptors reverses MK-801-induced behavioral impairments and enhances associative learning in rodents. ACS Chem Neurosci. 2014 Oct 15;5 (10) :920-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR4

Alternative Products

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MBS3844294-01VU0467154
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A19842-5VU0467154 5mg
A19842-50VU0467154 50mg
A19842-25VU0467154 25mg
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A19842-100VU0467154 100mg
A19842-10mM-DVU0467154 10mM * 1mL in DMSO

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