HH0043

CAT: 0804-HY-161714Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-161714Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

HH0043 (Compound 10f) is an orally active and potent SOS1 inhibitor, with IC50 value of 5.8 nM. HH0043 can be used for the research of cancer[1].

CAS Number

2922069-42-7

UNSPSC

12352005

Target

Ras; SOS1

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hh0043.html

Smiles

CC(N(CC1)CCN1C2=CC(C(N[C@H](C)C3=CC=CC(C(F)F)=C3F)=CC=N4)=C4C=N2)=O

Molecular Formula

C23H24F3N5O

Molecular Weight

443.46

References & Citations

[1]Li D, et al. Lead Identification of Novel Naphthyridine Derivatives as Potent SOS1 Inhibitors. ACS Med Chem Lett. 2024 Jun 3;15 (6) :958-964.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Alternative Products

Catalog	Name
T88773-01	HH0043