CD95 Antibody / Fas

CAT: 0013-GTR18317588-01Size: 20 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18317588-01Size:20 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MAb rB-R18 specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycoside-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro) . CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.

UniProt

P25445

Reactivity

Human

Immunogen

Recombinant human CD95 protein was used as the immunogen for the CD95 antibody.

Clonality

Recombinant

Clone

RB-R18

Conjugation

Unconjugated

Field of Research

Immunology & Inflammation; Cell Biology

Purification

Protein A/G affinity

Dilution

Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2ug/ml

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the CD95 antibody should be determined by the researcher.

Tested Applications

FACS, IF

Host or Source

Mouse

Preservative

0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide

Isotype

Mouse IgG2a, kappa

UniProtKB · P25445

Tumor necrosis factor receptor superfamily member 6

TNR6_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P25445
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: FAS
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: A9UJX4, B6VNV4, Q14292, Q14293, Q14294, Q14295, Q16652, Q5T9P1, Q5T9P2, Q5T9P3, Q6SSE9

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Molecular function

Calmodulin-bindingReceptor

Cellular component

Cell membraneMembraneSecreted

Disease

Disease variant

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix

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Alternative Products

Catalog	Name
70R-11592	CD95 antibody