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Desmin Antibody / DES

CAT: 0013-GTR18316893-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18316893-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain Alpha-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.
UniProt
P17661
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 270-470) from the human protein was used as the immunogen for the Desmin antibody.
Clonality
Recombinant
Clone
DES/8610R
Conjugation
Unconjugated
Field of Research
Musculoskeletal & Connective Tissue Research
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the Desmin antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Rabbit
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Rabbit IgG, kappa

UniProtKB · P17661

Desmin

DESM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17661
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DES
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q15787, Q549R7, Q549R8, Q549R9, Q8IZR1, Q8IZR6, Q8NES2, Q8NEU6, Q8TAC4, Q8TCX2, Q8TD99, Q9UHN5, Q9UJ80
Protein keywords

PTM

ADP-ribosylationMethylationPhosphoproteinUbl conjugation

Disease

CardiomyopathyDesmin-related myopathyDisease variantLimb-girdle muscular dystrophyMyofibrillar myopathy

Cellular component

Cell membraneCytoplasmIntermediate filamentMembraneNucleus

Domain

Coiled coil

Molecular function

Muscle protein

Technical term

Proteomics identificationReference proteome

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