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CD10 Antibody / CALLA / MME

CAT: 0013-GTR18316847Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18316847Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a 100kDa glycoprotein, identified as CD10, also known as Common Acute Lymphocytic Leukemia Antigen (CALLA) . It is a cell surface enzyme with neutral metalloendopeptidase activity, which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt s, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML) . It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue.CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells.
UniProt
P08473
Reactivity
Human
Immunogen
Recombinant human CD10 protein was used as the immunogen for the CD10 antibody.
Clonality
Recombinant
Clone
MME/8281R
Conjugation
Unconjugated
Field of Research
Neuroscience; Immunology & Inflammation
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT, Western blot: 2-4ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the CD10 antibody should be determined by the researcher.
Tested Applications
IHC-P, WB
Host or Source
Rabbit
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Rabbit IgG, kappa

UniProtKB · P08473

Neprilysin

NEP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08473
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MME
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.24.11
Processing
—
Secondary accessions
A8K6U6, D3DNJ9, Q3MIX4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneMembrane

Disease

Charcot-Marie-Tooth diseaseDisease variantNeurodegenerationNeuropathySpinocerebellar ataxia

PTM

Disulfide bondGlycoproteinLipoproteinMyristatePhosphoprotein

Molecular function

HydrolaseMetalloproteaseProtease

Ligand

Metal-bindingZinc

Domain

Signal-anchorTransmembraneTransmembrane helix

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