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BLIMP-1 Antibody / PRDM1

CAT: 0013-GTR18316648-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18316648-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The development and differentiation of plasma cells, which are terminally differentiated B-cells, are induced by Blimp-1 (B lymphocyte-induced maturation protein, also designated PRDI-BF1) . Blimp-1 is a transcriptional repressor that localizes to the nucleus and is considered a master regulator of terminal B-cell development. Alone, Blimp-1 is sufficient to trigger terminal B-cell differentiation. Blimp-1 upregulates the expression of syndecan-1 and J chain, represses IFN-b gene transcription and associates with HDAC to recruit it to DNA, thereby repressing c-Myc. Blimp-1 is expressed during the late stages of B-cell differentiation in immunoglobulin-secreting plasma cells, as well as in long-lived, bone marrow plasma cells. The expression of Blimp-1 defines a checkpoint beyond which fully activated B cells proceed to the plasma cell stage, whereas immature and partially activated cells are eliminated.
UniProt
O75626
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the BLIMP-1 antibody.
Clonality
Monoclonal
Clone
PCRP-PRDM1-2B9
Conjugation
Unconjugated
Field of Research
Signal Transduction
Purification
Protein A/G affinity
Dilution
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2ug/ml
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the BLIMP-1 antibody should be determined by the researcher.
Tested Applications
FACS, IF
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide
Isotype
Mouse IgG2a

UniProtKB · O75626

PR domain zinc finger protein 1

PRDM1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75626
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PRDM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.1.1.-
Processing
—
Secondary accessions
B2REA6, E1P5E0, Q86WM7
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityImmunityInnate immunityTranscriptionTranscription regulation

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Molecular function

DNA-bindingMethyltransferaseRepressorTransferase

PTM

Isopeptide bondUbl conjugation

Ligand

Metal-bindingS-adenosyl-L-methionineZinc

Domain

RepeatZinc-finger

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