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EPH Receptor B4 Antibody / EPHB4

CAT: 0013-GTR18316618Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18316618Size:100 µg
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Description
The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date. While the biological activities of these receptors have yet to be determined, there is increasing evidence that they are involved in central nervous system function and in development. The Eph subfamily receptors of human origin (and their murine/avian homologs) include EphA1 (Eph), EphA2 (Eck), EphA3 (Hek4), EphA4 (Hek8), EphA5 (Hek7), EphA6 (Hek12), EphA7 (Hek11/MDK1), EphA8 (Hek3), EphB1 (Hek6), EphB2 (Hek5), EphB3 (Cek10, Hek2), EphB4 (Htk), EphB5 (Hek9) and EphB6 (Mep) . Ligands for Eph receptors include ephrin-A4 (LERK-4) which binds EphA3 and EphB1. In addition, ephrin-A2 (ELF-1) has been described as the ligand for EphA4, ephrin-A3 (Ehk1-L) as the ligand for EphA5 and ephrin-B2 (Htk-L) as the ligand for EphB4 (Htk) .
UniProt
P54760
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the EPH Receptor B4 antibody.
Clonality
Monoclonal
Clone
EPHB4/6391
Conjugation
Unconjugated
Field of Research
Cardiovascular Research
Purification
Protein A/G affinity
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the EPH Receptor B4 antibody should be determined by the researcher.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
1 mg/ml in 1X PBS; rAlbumin free, sodium azide free
Isotype
Mouse IgG2, kappa

UniProtKB · P54760

Ephrin type-B receptor 4

EPHB4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P54760
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EPHB4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
B5A970, B5A971, B5A972, Q7Z635, Q9BTA5, Q9BXP0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Angiogenesis

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneMembrane

Molecular function

Developmental proteinKinaseReceptorTransferaseTyrosine-protein kinase

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

RepeatSignalTransmembraneTransmembrane helix

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