3-O-Methyltolcapone-d7

3-O-Methyltolcapone-d7

• UNSPSC Description: 3-O-Methyltolcapone-d7 is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone is a metabolite of Tolcapone. Tolcapone is an orally active, reversible, selective and potent COMT inhibitor. Tolcapone crosses the blood-brain barrier, and can be used for treatment of Parkinson's disease[1][2].
• Target Antigen: COMT
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease;Neuronal Signaling
• Applications: Neuroscience-Neurodegeneration
• Field of Research: Neurological Disease
• Purity: 99.0
• Solubility: 10 mM in DMSO
• Smiles: OC(C(OC)=C1)=C(C=C1C(C2=C([2H])C([2H])=C(C([2H])=C2[2H])C([2H])([2H])[2H])=O)[N+]([O-])=O
• Molecular Weight: 294.31
• References & Citations: [1]Jorga K, et al. Metabolism and excretion of tolcapone, a novel inhibitor of catechol-O-methyltransferase. Br J Clin Pharmacol. 1999 Oct;48(4):513-20.|[2]Ceravolo R, et al. 18F-dopa PET evidence that tolcapone acts as a central COMT inhibitor in Parkinson's disease. Synapse. 2002 Mar 1;43(3):201-7.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported