AF488 Anti-Mouse CD54 Antibody

• Background:

  CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) . CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

• Synonyms:

  Intercellular adhesion molecule 1, Icam1, MALA-2, MyD10, CD54, Icam-1

• Gene ID:

  15894

• Swiss Prot:

  P13597

• Host:

  Rat

• Reactivity:

  Mouse

• Isotype:

  IgG2b κ

• Conjugation:

  AF488

• Applications:

  FCM

• Buffer:

  PBS with 0.05% Proclin300, 1% BSA

• Storage Conditions:

  Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.

• CAS Number:

  9007-83-4