4-trans-Hydroxy-glibenclamide

4-trans-Hydroxy-glibenclamide

• CAS Number: 23155-00-2
• UNSPSC Description: rac-trans-4-hydroxy Glyburide is an active metabolite of the SUR1/Kir6.2 sulfonylurea inhibitor glyburide (HY-15206). It is formed from glyburide by the cytochrome P450 (CYP) isoforms CYP2C8 and CYP2C9. rac-trans-4-hydroxy Glyburide inhibits glyburide binding to rat brain synaptosomes at the high and low affinity sites of SUR1/Kir6.2 with IC50 values of 0.95 and 100 nM, respectively.
• Target Antigen: Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/4-trans-hydroxy-glibenclamide.html
• Smiles: O=C(NCCC1=CC=C(S(=O)(NC(N[C@H]2CC[C@H](O)CC2)=O)=O)C=C1)C3=CC(Cl)=CC=C3OC
• Molecular Weight: 510.00
• References & Citations: [1]Zharikova, et al. Identification of the major human hepatic and placental enzymes responsible for the biotransformation of glyburide. Biochem. Pharmacol. 78(12), 1483-1490 (2009).
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported