D-Leu-Pro-Arg-Rh110-D-Pro (TFA)

D-Leu-Pro-Arg-Rh110-D-Pro (TFA)

• UNSPSC Description: D-Leu-Pro-Arg-Rh110-D-Pro TFA is a substrate for Factor Xa I (FXIa) with binding affinity. D-Leu-Pro-Arg-Rh110-D-Pro TFA consists of Rhodamine 110 (HY-D0817) linked to a peptide chain through a cleavable bond. Cleavable bond cleavage enhances fluorophore intensity. D-Leu-Pro-Arg-Rh110-D-Pro TFA can be used to detect FXIa activity[1].
• Target Antigen: Factor Xa
• Type: Peptides
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/d-leu-pro-arg-rh110-d-pro-tfa.html
• Purity: 99.59
• Solubility: 10 mM in DMSO
• Smiles: O=C1OC2(C3=CC=C(C=C3OC4=CC(NC([C@@H]5NCCC5)=O)=CC=C24)NC([C@@H](NC([C@H]6N(CCC6)C([C@H](N)CC(C)C)=O)=O)CCCNC(N)=N)=O)C7=CC=CC=C71.O=C(C(F)(F)F)O.[x]
• Molecular Weight: 793.91 (free base)
• References & Citations: [1]Lorthiois E, et al. Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach. J Med Chem. 2020 Aug 13;63(15):8088-8113.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
• Clinical Information: No Development Reported