CD7 Antibody

CAT: 0013-GTR18317245-02Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0013-GTR18317245-02Size:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Recognizes a protein of 40kDa, identified as CD7 (also known as gp40, Leu9) . CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation.

UniProt

P09564

Reactivity

Human

Immunogen

A recombinant partial protein sequence (within amino acids 1-240) from the human protein was used as the immunogen for the CD7 antibody.

Clonality

Recombinant

Clone

CD7/8118R

Conjugation

Unconjugated

Field of Research

Immunology & Inflammation

Purification

Protein A/G affinity

Dilution

Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Applications Notes

Optimal dilution of the CD7 antibody should be determined by the researcher.

Tested Applications

IHC-P

Host or Source

Rabbit

Preservative

0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin, 0.05% sodium azide

Isotype

Rabbit IgG, kappa

UniProtKB · P09564

T-cell antigen CD7

CD7_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P09564
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CD7
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: —

Protein keywords

Biological process

Adaptive immunityImmunity

PTM

Disulfide bondGlycoproteinLipoproteinPalmitate

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Cellular component

Membrane

Technical term

Proteomics identificationReference proteome

Molecular function

Receptor

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