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OUL245

CAT: 0804-HY-W294889Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W294889Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OUL245 is a 7-Hydroxy derivative, and a selectively PARP2 inhibitor (IC50=44 nM) . OUL245 also inhibits other PARP and TNKS enzymes with IC50s of 2.9-8.8 μM[1].
CAS Number
1023814-45-0
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/oul245.html
Solubility
10 mM in DMSO
Smiles
C1=CC2=C(C=C1O)SC3=NN=CN23
Molecular Formula
C8H5N3OS
Molecular Weight
191.21
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Murthy S, et al. [1,2,4]Triazolo[3,4-b]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. J Med Chem. 2023 Jan 4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1; PARP10; PARP14; PARP15; PARP2; PARP3; PARP4; TNKS1/PARP5A; TNKS2/PARP5B

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