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Denagliptin

CAT: 0804-HY-167680-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-167680-01Size:1 mg
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Description
Denagliptin (GSK823093) is a small molecule dipeptidyl peptidase IV (DPP-4) inhibitor with activity for the suppression of endocrine and metabolic diseases. Denagliptin can be used to study type 2 diabetes. Denagliptin is stable in the solid state but degrades in solution and in mixtures with various excipients. Denagliptin also exhibits degradation in capsules, mainly through cyclization reactions to form (3S,7S,8aS) aminoamines to provide further synthetic materials. The degradation pathway of Denagliptin was elucidated, providing data to support its formulation development and regulatory filings[1].
CAS Number
483369-58-0
Product Name Alternative
GSK823093
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/denagliptin.html
Smiles
O=C(N1[C@@H](C[C@@H](C1)F)C#N)[C@@H](N)C(C2=CC=C(C=C2)F)C3=CC=C(C=C3)F
Molecular Formula
C20H18F3N3O
Molecular Weight
373.37
References & Citations
[1]Elucidating the pathways of degradation of denagliptin
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3

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