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AS2717638

CAT: 0804-HY-114379-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114379-01Size:5 mg
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Description
AS2717638 is a highly selective, brain-penetrant and orally active lysophosphatidic acid receptor 5 (LPA5) antagonist with an IC50 value of 38 nM. AS2717638 is highly selective and shows no significant antagonistic activity against other LPA receptors (LPA1, LPA2, and LPA3) . AS2717638 can be used in the research of pain and neuroinflammation-related diseases[1][2].
CAS Number
2148339-28-8
Product Name Alternative
OPC-14857 (Standard); DM-14857 (Standard), OPC-14857; DM-14857
UNSPSC
12352005
Target
LPL Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/AS2717638.html
Purity
99.85
Solubility
DMSO : 60 mg/mL (ultrasonic)
Smiles
O=C1N(C=C(C2=C1C=C(C(OC)=C2)OC)C(N3CCCCC3)=O)C4=NOC5=C4C=C(C=C5)C
Molecular Formula
C25H25N3O5
Molecular Weight
447.48
References & Citations
[1]Murai N, et al. Analgesic effects of novel lysophosphatidic acid receptor 5 antagonist AS2717638 in rodents. Neuropharmacology. 2017 Nov;126:97-107.|[2]Joshi L, et al. Inhibition of Autotaxin and Lysophosphatidic Acid Receptor 5 Attenuates Neuroinflammation in LPS-Activated BV-2 Microglia and a Mouse Endotoxemia Model. Int J Mol Sci. 2021 Aug 7;22 (16) :8519.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LPAR5

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