Anti-α-1-antitrypsin Antibody
CAT:
14-13701-100-1
Size:
100 µg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Anti-α-1-antitrypsin Antibody
- Description: Mouse Monoclonal Antibody specific to α-1-antitrypsin
- Alternative Name: α-1 protease inhibitor, α-1-antiproteinase, Serpin A1 [Cleaved into: Short peptide from AAT
- Gene Name: SERPINA1
- NCBI Gene ID: SERPINA1
- UniProt: P01009
- Cellular Locus: Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum.; [Short peptide from AAT]: Secreted, extracellular space, extracellular matrix.
- Host: Mouse
- Reactivity: Human
- Immunogen: Purified human serum alpha-1-antitrypsin.
- Target Antigen: α-1-antitrypsin
- Target: α-1-antitrypsin
- Clonality: Monoclonal
- Isotype: IgG2a
- Type: Antibody
- Applications: ELISA
- Field of Research: Enzymes
- Purification Method: Purified by protein G affinity chromatography
- Concentration: Lot Specific
- Dilution: Dilute in PBS or medium that is identical to that used in the assay system.
- Format: Purified
- Form: Liquid
- Buffer: Phosphate Buffered Saline
- Function: Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.; [Short peptide from AAT]: Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).
- Additionnal Information: These antibodies have been qualified for use in ELISA to detect human a1AT.
End users should determine optimal concentrations for their applications. - Storage Conditions: These antibodies are stable for at least one (1) year at -20ºC to -70ºC. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
- Specificity: α-1-antitrypsin
- Formulation: PBS, pH 7.4.
- Buffer pH: pH 7.4