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PDK1 antibody

CAT: 0710-FNab10419Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab10419Size:100 µg
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Background
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Synonyms
[Pyruvate dehydrogenase (acetyl-transferring) ] kinase isozyme 1, mitochondrial|Pyruvate dehydrogenase kinase isoform 1 (PDH kinase 1) |PDK1|PDHK1
Gene ID
5163
UniProt
Q15118
Host
Rabbit
Reactivity
Human
Immunogen
Pyruvate dehydrogenase kinase, isozyme 1
Target
PDK1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB
Immunogen Sequence
92-151aa

UniProtKB · Q15118

[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial

PDK1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15118
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDK1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.2
Processing
Precursor
Secondary accessions
B2R6T1, B7Z937, D3DPD8, E9PD65, Q308M4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Molecular function

KinaseTransferase

Cellular component

Mitochondrion

PTM

Phosphoprotein

Domain

Transit peptide

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