IκB-α (phospho-Ser32) rabbit pAb

• Background:

  This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]

• Description:

  This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011],

• UniProt:

  P25963

• Swiss Prot:

  P25963

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  Synthesized phosho peptide around human IκBα (Ser32)

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IHC

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000; IHC-p 1:50-300

• Molecular Weight:

  about 40kd

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  About 40kd

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. .

• Other Product Names:

  NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)

• Gene ID (Human):

  4792