Cd1a

• Description :

  Cd1a is a β-toxin derived from the African spider Ceratogyrus darlingi. Cd1a can regulate calcium ion channels. Cd1a inhibits human calcium ion channels (Cav2.2) (IC502.6 μM) and mouse sodium ion channels (Nav1.7) . Cd1a can be used in the development of peripheral pain treatment drugs [1].

• Product Name Alternative :

  β-TRTX-cd1a; β-Theraphotoxin-cd1a

• UNSPSC :

  12352209

• Target :

  Calcium Channel

• Type :

  Peptides

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/cd1a.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC(C)C)=O)CC(O)=O)=O)CC4=CC=C(O)C=C4)=O)CCCCN)=O)=O)CCCCN)=O)CC(O)=O)=O)CC(N)=O)=O)CCCCN)=O)CCC1)=O)CC(O)=O)=O)CSSC[C@H](NC5=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CC6=CNC7=CC=CC=C67)=O)CCCNC(N)=N)=O)CC(O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CO)=O)=O)CO)=O)CCCCN)=O)CC8=CC=CC=C8)=O)CC9=CNC%10=CC=CC=C9%10)=O)=O)CC(C)C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]5CO)=O)CC%11=CC=C(O)C=C%11)=O)CC(N)=O)=O)CCCCN)=O

• Molecular Formula :

  C171H254N52O50S6

• Molecular Weight :

  4030.55

• References & Citations :

  [1]Sousa SR, et al. Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. PLoS One. 2017 Sep 7;12 (9) :e0182848.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported