Casein Kinase inhibitor A86
CAT:
804-HY-123955-03
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Casein Kinase inhibitor A86
- CAS Number: 2079069-01-3
- UNSPSC Description: Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor. Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities[1].
- Target Antigen: Apoptosis; Casein Kinase; CDK
- Type: Reference compound
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Stem Cell/Wnt
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/casein-kinase-inhibitor-a86.html
- Purity: 99.26
- Solubility: DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: N[C@H]1CC[C@H](NC2=NC=C(F)C(C3=C(CC4CC4)N(C)N=C3)=N2)CC1
- Molecular Weight: 344.43
- References & Citations: [1]Waleed Minzel, et al. Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell. 2018 Sep 20;175(1):171-185.e25.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported