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PV1162

CAT: 0804-HY-164523Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-164523Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PV1162 is a selective Chk2 inhibitor with an IC50 of 0.29 nM. PV1162 inhibits ATP binding to Chk2 by targeting the gatekeeper-dependent hydrophobic pocket, which is specific to Chk2 and located behind the ATP-binding site (adenine-binding region), thereby inhibiting the phosphorylation activity of Chk2. PV1162 holds potential application value in the field of cancer therapy[1].
CAS Number
1093793-11-3
UNSPSC
12352005
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pv1162.html
Smiles
O=C(C(N1)=CC2=C1C=CC(OC)=C2)NC3=CC=C(/C(CCC)=N/NC(N)=N)C=C3
Molecular Formula
C21H24N6O2
Molecular Weight
392.45
References & Citations
[1]Lountos GT, et al. X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket. FEBS Lett. 2011 Oct 20;585 (20) :3245-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1; Chk2

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