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MMV688533

CAT: 0804-HY-148178Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148178Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MMV688533 is an antimalarial agent with rapid anti-plasmodial activity and effective single-dose activity against Plasmodium falciparum infection in humanized mouse models. MMV688533 can inhibit the activity of asexual blood stage parasites with an IC50 value of 1.3 nM. MMV688533 exhibits excellent pharmacokinetic properties and safety[1].
CAS Number
2260904-47-8
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/mmv688533.html
Purity
99.72
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(C#CC2=CC=C(C(F)(F)F)C(C(NC3=NC=CC=C3)=O)=C2)=CC(C(F)(F)F)=C1)NC(N)=N
Molecular Formula
C24H15F6N5O2
Molecular Weight
519.40
References & Citations
[1]Murithi J M, et al. The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance[J]. Science translational medicine, 2021, 13 (603) : eabg6013.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

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CatalogName
T67695-01MMV688533

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