BMS-1166-N-piperidine-CO-N-piperazine (dihydrochloride)

BMS-1166-N-piperidine-CO-N-piperazine (dihydrochloride)

• CAS Number: 2691796-83-3
• UNSPSC Description: BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride incorporates a ligand for PD-1/PD-L1 immune checkpoint, and a PROTAC linker. BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride can be used in the synthesis of PROTAC PD-1/PD-L1 degrader-1?(HY-131183). PROTAC PD-1/PD-L1 degrader-1 inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM[1].
• Target Antigen: Target Protein Ligand-Linker Conjugates
• Type: Reference compound
• Related Pathways: PROTAC
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/bms-1166-n-piperidine-co-n-piperazine-dihydrochloride.html
• Purity: 95.01
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: N#CC1=CC=CC(COC2=CC(OCC3=CC=CC(C4=CC=C5OCCOC5=C4)=C3C)=C(C=C2CN6CCCCC6C(N7CCNCC7)=O)Cl)=C1.Cl.Cl
• Molecular Weight: 780.18
• References & Citations: [1]Cheng B, Ren Y, Cao H, Chen J. Discovery of novel resorcinol diphenyl ether-based PROTAC-like molecules as dual inhibitors and degraders of PD-L1. Eur J Med Chem. 2020;199:112377.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported