MAP855

• Description :

  MAP855 is a highly potent, selective, ATP-competitive and orally active MEK1/2 kinase inhibitor (MEK1 ERK2 cascade IC50=3 nM, pERK EC50=5 nM) . MAP855 shows equipotent inhibition of wild-type and mutant MEK1/2[1].

• UNSPSC :

  12352005

• Target :

  ERK; MEK

• Type :

  Reference compound

• Related Pathways :

  MAPK/ERK Pathway; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/map855.html

• Purity :

  98.48

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC1=NC2=C(C3=CC(C4=C(C=C(C=C4)OC5=NC=CC=N5)Cl)=C(F)C=C3N=C2)N1[C@]6([H])[C@H](CN(CC6)C(CO)=O)F

• Molecular Formula :

  C28H23ClF2N6O3

• Molecular Weight :

  564.97

• References & Citations :

  [1]Poddutoori R, et al. Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action. J Med Chem. 2022;65 (5) :4350-4366.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ERK; MEK1

• CAS Number :

  [1660107-77-6]