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JGB1741

CAT: 0804-HY-111329-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-111329-01Size:1 mg
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Description
JGB1741 (ILS-JGB-1741) is a potent and specific SIRT1 activity inhibitor with an IC50 of ～15 μM. JGB1741 is a weak SIRT2 and SIRT3 inhibitor with an all IC50>100 μM. JGB1741 increases the acetylated p53 levels leading to p53-mediated apoptosis with modulation of Bax/Bcl2 ratio, cytochrome c release and PARP cleavage. JGB1741 has the potential for breast cancer research[1].
CAS Number
[1256375-38-8]
Product Name Alternative
ILS-JGB-1741
UNSPSC
12352005
Target
Apoptosis; Sirtuin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jgb1741.html
Purity
99.37
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
OC1=C(C2=C(C=C1)C=CC=C2)/C=N/C3=C(C4=C(S3)CCCC4)C(NCC5=CC=CC=C5)=O
Molecular Formula
C27H24N2O2S
Molecular Weight
440.56
References & Citations
[1]Arunasree M Kalle, et al. Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2010 Oct 8;401 (1) :13-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2; SIRT3

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