TI17

• Description :

  TI17 is an inhibitor of the thyroid hormone receptor-interacting protein Trip13 and has anticancer activity. TI17 effectively inhibits multiple myeloma (MM) cell proliferation and induces cell cycle arrest and apoptosis. Trip13 is an AAA-ATPase that mediates double-strand break (DSB) repair; TI17 inhibits Trip13 function and increases DNA damage[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Thyroid Hormone Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ti17.html

• Purity :

  97.0

• Solubility :

  10 mM in DMSO

• Smiles :

  OC(C1C2C=CC(C1C(NC3=CC=C(C=C3)CC4=CC=NC=C4)=O)C5CC25)=O

• Molecular Formula :

  C23H22N2O3

• Molecular Weight :

  374.44

• References & Citations :

  [1]Chang S et al. TI17, a novel compound, exerts anti-MM activity by impairing Trip13 function of DSBs repair and enhancing DNA damage. Cancer Med. 2023 Nov 9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Dedicated for Diverse Library

• Clinical Information :

  No Development Reported

• CAS Number :

  [1005178-02-8]