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UMB24

CAT: 0804-HY-14222Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14222Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UMB24 is a potent antagonist of σ2 receptor, with Ki values of 170 nM anf 322 nM for σ2 receptor and σ1 receptor, respectively. UMB24 attenuats cocaine-induced convulsions and locomotor activity, but not lethality[1].
CAS Number
1033-69-8
UNSPSC
12352005
Target
Sigma Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/umb24.html
Smiles
C1(N2CCN(CC2)CCC3=CC=CC=C3)=NC=CC=C1
Molecular Formula
C17H21N3
Molecular Weight
267.37
References & Citations
[1]Rae R Matsumoto, et al. Effects of UMB24 and (±) -SM 21, putative σ2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in mice. Pharmacol Biochem Behav. 2007 Jan;86 (1) :86-91.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Sigma 1 Receptor; Sigma 2 Receptor

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BAA03369-01UMB24
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