4-(Chloromethyl)-7-hydroxycoumarin

4-(Chloromethyl)-7-hydroxycoumarin

• CAS Number: 25392-41-0
• UNSPSC Description: 4-(Chloromethyl)-7-hydroxycoumarin (compound 4) is a hydroxycoumarin derivative with potent antioxidant effect and high hydroxyl radical-scavenging property. 4-(Chloromethyl)-7-hydroxycoumarin contains a methyl group and a chlorine group in the heterocyclic ring. A series of coumarins incorporating hydroxy-, chloro- and/or chloromethyl-moieties has been investigated as potent inhibitors of the zinc enzyme carbonic anhydrase, expecially tumor-associated isoforms CA IX and XII[1][2].
• Target Antigen: Others
• Type: Reference compound
• Related Pathways: Others
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/4-chloromethyl-7-hydroxycoumarin.html
• Purity: 97.96
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: O=C1OC(C=C2O)=C(C=C2)C(CCl)=C1
• Molecular Weight: 210.616
• References & Citations: [1]Fernanda Pérez-Cruz, et al. Selected hydroxycoumarins as antioxidants in cells: physicochemical and reactive oxygen species scavenging studies. 2013, Oct. 26(10):773-783. |[2]Knaus E E , et al. Phenylethynylbenzenesulfonamide regioisomers strongly and selectively inhibit the transmembrane, tumor-associated carbonic anhydrase isoforms IX and XII over the cytosolic isoforms I and II[J]. Bioorganic & Medicinal Chemistry Letters, 2011, 21(19):5892-5896.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported