SARS-CoV-2 nsp3-IN-1

SARS-CoV-2 nsp3-IN-1

• CAS Number: 2892105-43-8
• UNSPSC Description: SARS-CoV-2 nsp3-IN-1 (Compound 15c) is a Mac1 (SARS-CoV-2 nsp3 macrodomain) inhibitor with the IC50 value of 6.1 μM. SARS-CoV-2 nsp3-IN-1 can inhibit Mac1 ADP-ribosylhydrolase activity. SARS-CoV-2 nsp3-IN-1 demonstrates notable selectivity for coronavirus macrodomains, especially towards SARS-CoV-2 Mac1[1].
• Target Antigen: SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sars-cov-2-nsp3-in-1.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: OC([C@H](CC1=CNC2=C1C=CC=C2)NC3=NC=NC4=C3C=CN4)=O
• Molecular Weight: 321.33
• References & Citations: [1]Lavinia M Sherrill, et al. Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV2 nsp3 Macrodomain. bioRxiv. 2022 Feb 28:2022.02.27.482176.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported