Netupitant

CAT:
804-HY-16346-01
Size:
5 mg
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Netupitant - image 1

Netupitant

  • UNSPSC Description:

    Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK1) receptor antagonist with a Ki of 0.95 nM for hNK1 in CHO cells. Netupitant has antiemetic affect[1][2][3].
  • Target Antigen:

    Neurokinin Receptor
  • Type:

    Reference compound
  • Related Pathways:

    GPCR/G Protein;Neuronal Signaling
  • Applications:

    Neuroscience-Neuromodulation
  • Field of Research:

    Neurological Disease; Endocrinology; Cancer
  • Assay Protocol:

    https://www.medchemexpress.com/Netupitant.html
  • Solubility:

    DMSO : 9.09 mg/mL (ultrasonic;warming;heat to 60°C)
  • Smiles:

    CN1CCN(C2=CC(C3=C(C)C=CC=C3)=C(N(C)C(C(C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)(C)C)=O)C=N2)CC1
  • Molecular Weight:

    578.59
  • References & Citations:

    [1]Hoffmann T, et al. Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1362-5.|[2]Rizzi A, et al. In vitro and in vivo pharmacological characterization of the novel NK1 receptor selective antagonist Netupitant. Peptides. 2012 Sep;37(1):86-97.|[3]Stefano Palea, et al. Netupitant, a Potent and Highly Selective NK1 Receptor Antagonist, Alleviates Acetic Acid-Induced Bladder Overactivity in Anesthetized Guinea-Pigs. Front Pharmacol. 2016 Aug 4;7:234.
  • Shipping Conditions:

    Room Temperature
  • Clinical Information:

    Launched
  • CAS Number:

    290297-26-6