Netupitant
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Netupitant
UNSPSC Description:
Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK1) receptor antagonist with a Ki of 0.95 nM for hNK1 in CHO cells. Netupitant has antiemetic affect[1][2][3].Target Antigen:
Neurokinin ReceptorType:
Reference compoundRelated Pathways:
GPCR/G Protein;Neuronal SignalingApplications:
Neuroscience-NeuromodulationField of Research:
Neurological Disease; Endocrinology; CancerAssay Protocol:
https://www.medchemexpress.com/Netupitant.htmlSolubility:
DMSO : 9.09 mg/mL (ultrasonic;warming;heat to 60°C)Smiles:
CN1CCN(C2=CC(C3=C(C)C=CC=C3)=C(N(C)C(C(C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)(C)C)=O)C=N2)CC1Molecular Weight:
578.59References & Citations:
[1]Hoffmann T, et al. Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1362-5.|[2]Rizzi A, et al. In vitro and in vivo pharmacological characterization of the novel NK1 receptor selective antagonist Netupitant. Peptides. 2012 Sep;37(1):86-97.|[3]Stefano Palea, et al. Netupitant, a Potent and Highly Selective NK1 Receptor Antagonist, Alleviates Acetic Acid-Induced Bladder Overactivity in Anesthetized Guinea-Pigs. Front Pharmacol. 2016 Aug 4;7:234.Shipping Conditions:
Room TemperatureClinical Information:
LaunchedCAS Number:
290297-26-6