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α-Methylserotonin

CAT: 0804-HY-145463-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-145463-01Size:5 mg
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Description
α-Methylserotonin is a potent and selective agonist of 5-HT2 receptor. α-Methylserotonin is an analogue of serotonin formed in vivo from α-methyltryptophan. α-Methylserotonin mediates the lymphatic smooth muscle contraction and prevents the up-regulation of serotonin-receptor-mediated phosphoinositide hydrolysis[1][2][3].
CAS Number
304-52-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/α-methylserotonin.html
Purity
95.0
Solubility
DMSO : 50 mg/mL (ultrasonic) |Methanol : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
OC1=CC2=C(NC=C2CC(C)N)C=C1
Molecular Formula
C11H14N2O
Molecular Weight
190.24
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
References & Citations
[1]Dobbins DE. Receptor mechanisms of serotonin-induced prenodal lymphatic constriction in the canine forelimb. Am J Physiol. 1998 Feb;274 (2) :H650-4.|[2]Brumley MR, et al. The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus. Behav Neurosci. 2005 Jun;119 (3) :821-33.|[3]Edwards E, et al. (+/-) -1- (2,5-Dimethoxy-4-iodophenyl) -2-aminopropane (DOI) and alpha-methyl-5-HT: 5-HT2 receptor agonistic action on phosphatidylinositol metabolism in the rat fronto-cingulate and entorhinal cortex. Neuropharmacology. 1992 Jul;31 (7) :615-21.|[4]Brumley MR, et al. The serotonergic agonists quipazine, CGS-12066A, and alpha-methylserotonin alter motor activity and induce hindlimb stepping in the intact and spinal rat fetus. Behav Neurosci. 2005 Jun;119 (3) :821-33.|[5]Edwards E, et al. (+/-) -1- (2,5-Dimethoxy-4-iodophenyl) -2-aminopropane (DOI) and alpha-methyl-5-HT: 5-HT2 receptor agonistic action on phosphatidylinositol metabolism in the rat fronto-cingulate and entorhinal cortex. Neuropharmacology. 1992 Jul;31 (7) :615-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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