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A-953227

CAT: 0804-HY-114584Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-114584Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A-953227 is a highly potent and selective inhibitor with the activity of inhibiting calcium-dependent esterase (calpain) . A-953227 has enhanced selectivity for related cysteine proteases (cathepsins) and has shown good efficacy in cell experiments. A-953227 has shown broad efficacy in preclinical models for Alzheimer's disease, suggesting that it has potential benefits in inhibiting Alzheimer's disease[1].
CAS Number
1037826-77-9
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/a-953227.html
Smiles
O=C(C1=C(N=CC=C1)N2N=C(C=C2)C3=CC=C(C=C3)F)NC(CC4=CC=CC=C4)C(C(N)=O)=O
Molecular Formula
C25H20FN5O3
Molecular Weight
457.46
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2- (3-Phenyl-1H-pyrazol-1-yl) -nicotinamides
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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