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LEO 29102

CAT: 0804-HY-12348Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12348Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LEO 29102 is a potent phosphodiesterase 4 (PDE4) inhibitor with an IC50 value of 5 nM. LEO 29102 inhibits TNFα release. LEO 29102 has the potential for the research of atopic dermatitis[1].
CAS Number
1035572-38-3
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/leo-29102.html
Smiles
COC1=C(C=CC(C(CC2=C(C=NC=C2Cl)Cl)=O)=C1OCC(NCCC)=O)OC
Molecular Formula
C20H22Cl2N2O5
Molecular Weight
441.31
References & Citations
[1]Felding J, et al. Discovery and early clinical development of 2-{6-[2- (3,5-dichloro-4-pyridyl) acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis. J Med Chem. 2014 Jul 24;57 (14) :5893-903.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
PDE4

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