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L 741742

CAT: 0804-HY-101349Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101349Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L 741742 is a dopamine receptor D4 (DRD4) antagonist that selectively inhibits glioblastomas (GBM) growth in vitro and in vivo, synergyed with Temozolomide (TMZ). L 741742 disrupts in effectors PDGFRβ/ERK1/2 and mTOR signaling. Additionally, L 741742 disrupts endolysosmal function compromising the autophagy-lysosomal degradation pathway, followed by G0/G1 cell cycle arrest and Apoptosis. L 741742 is promising for research of GBM and neurogenesis[1].
CAS Number
156337-32-5
UNSPSC
12352005
Target
Apoptosis; Dopamine Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l-741742.html
Smiles
CC1=C(C2=CC=C(Cl)C=C2)ON=C1C3CCN(CCC4=CC=CC=C4)CC3
Molecular Formula
C23H25ClN2O
Molecular Weight
380.91
References & Citations
[1]Dolma S. Investigation of Neurochemicals' Role in Glioblastoma and Neural Stem Cells: Characterization of Dopamine Receptor D4 Inhibition in Glioblastoma Stem Cells[M]. University of Toronto (Canada), 2016.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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