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Protopine (hydrochloride)

CAT: 0804-HY-N0793ASize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0793ASize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Protopine hydrochloride, an isoquinoline alkaloid, is a specific reversible and competitive inhibitor of acetylcholinesterase. Protopine hydrochloride exhibits anti-inflammation, anti-microbial, anti-angiogenic and anti-tumour activity[1][2].
CAS Number
6164-47-2
Product Name Alternative
Corydinine (hydrochloride)
UNSPSC
12352005
Hazard Statement
H301
Target
Cholinesterase (ChE)
Type
Natural Products
Related Pathways
Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/protopine-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C1CC2=C(CN(CCC3=CC4=C(C=C31)OCO4)C)C5=C(C=C2)OCO5.Cl
Molecular Formula
C20H20ClNO5
Molecular Weight
389.83
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]Kim SR, et, al. Protopine from Corydalis ternata has anticholinesterase and antiamnesic activities. Planta Med. 1999 Apr;65 (3) :218-21. |[2]Nie C, et, al. Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma. Cancer Cell Int. 2021 Jul 27;21 (1) :396.|[3]Xu LF, et al. Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models. Neuropharmacology. 2006 Jun;50 (8) :934-40. |[4]Xiao X, et al. Protective effect of protopine on the focal cerebral ischaemic injury in rats. Basic Clin Pharmacol Toxicol. 2007 Aug;101 (2) :85-9.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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