BRD4/NAMPT-IN-1
CAT:
804-HY-161515-02
Size:
25 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
BRD4/NAMPT-IN-1
- CAS Number: 3049218-28-9
- UNSPSC Description: BRD4/NAMPT-IN-1 (Compound A2) shows strong inhibitory effects on NAMPT and BRD4 (IC50=35 nM (NAMPT) and 58 nM (BRD4)). BRD4/NAMPT-IN-1 inhibits the growth and migration of hepatocellular carcinoma cells and promotes apoptosis. BRD4/NAMPT-IN-1 also shows potent anticancer effects in HCCLM3 xenograft mouse model, with no obvious toxic effects[1].
- Target Antigen: Epigenetic Reader Domain; NAMPT
- Type: Reference compound
- Related Pathways: Epigenetics;Metabolic Enzyme/Protease
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/brd4-nampt-in-1.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: ClC(C=C1)=CC=C1C2=N[C@@H](CC(NCCCNC(/C=C/C3=CN=CC=C3)=O)=O)C4=NN=C(C)N4C5=C2C(C)=C(C)S5
- Molecular Weight: 588.12
- References & Citations: [1]Yin C, et al. Discovery of potent and novel dual NAMPT/BRD4 inhibitors for efficient treatment of hepatocellular carcinoma. Eur J Med Chem. 2024 May 5;271:116444.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported