Products for Research Use Only
RegisterLogin

Traxanox

CAT: 0804-HY-167715-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-167715-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Traxanox is an orally available diuretic that enhances phagocytosis of yeast granules by mouse peritoneal macrophages and rat peritoneal polymorphonuclear leukocytes in vitro. Traxanox inhibits IgE-mediated histamine release and cyclic AMP phosphodiesterase activity.Traxanox exhibits anti-inflammatory activity, as it inhibits the anaphylactoid reaction and reduces pleural fluid accumulation in experimental models of inflammation. Traxanox also demonstrates a synergistic effect when combined with hydrocortisone or indomethacin in suppressing adjuvant arthritis in rats.
CAS Number
58712-69-9
UNSPSC
12352005
Target
Histamine Receptor; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/traxanox.html
Smiles
O=C1C2=CC=CN=C2OC3=C1C=C(C4=NN=NN4)C=C3Cl
Molecular Formula
C13H6ClN5O2
Molecular Weight
299.67
References & Citations
[1][Effect of traxanox sodium on inflammatory response]|[2]Goto K, et al. Inhibitory effect of traxanox sodium on IgE-mediated histamine release from passively-sensitized mast cells of the rat in vitro. Int Arch Allergy Appl Immunol. 1982;68 (4) :332-337. |[3]Ikegami K, et al. The effects of traxanox sodium of cyclic AMP phosphodiesterase and the concentration of cyclic AMP in the plasma of rats. Chem Pharm Bull (Tokyo) . 1983 Feb;31 (2) :752-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19213645-01Traxanox
MBS5784400Traxanox sodium
MBS5810730Traxanox TFA

Popular Products