Ex26

• Description:

  Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 (S1P1) antagonist (IC50=0.93 nM) . Ex26 shows >3,000-fold selectivity for S1P1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach[1].

• Product Name Alternative:

  S1P1-IN-Ex26

• UNSPSC:

  12352005

• Target:

  LPL Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease; Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ex26.html

• Purity:

  99.4

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)C1(CC1)NC(C2=C(C=C(C=C2C)C3=CC(NC(C)C4=CC=C(C(C)=C4)Cl)=CC=C3F)C)=O

• Molecular Formula:

  C28H28ClFN2O3

• Molecular Weight:

  494.98

• References & Citations:

  [1]Stuart M Cahalan, et al. Sphingosine 1-phosphate receptor 1 (S1P (1) ) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P (1) antagonist. Mol Pharmacol. 2013 Feb;83 (2) :316-21.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1233332-37-0]