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Kazinol B

CAT: 0804-HY-N3426Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N3426Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Kazinol B, a prenylated flavan with a dimethyl pyrane ring, is an inhibitor of nitric oxide (NO) production. Kazinol B improves insulin sensitivity by enhancing glucose uptake via the insulin-Akt signaling pathway and AMPK activation. Kazinol B has the potential for diabetes mellitus research[1][2].
CAS Number
99624-27-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Akt; AMPK; NO Synthase
Type
Natural Products
Related Pathways
Epigenetics; Immunology/Inflammation; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/kazinol-b.html
Solubility
10 mM in DMSO
Smiles
C/C(C)=C/CC1=C([C@H]2OC3=CC(O)=CC=C3CC2)C=C4C(OC(C)(C)C=C4)=C1O
Molecular Formula
C25H28O4
Molecular Weight
392.49
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Hyejin Lee, et al. Kazinol B from Broussonetia kazinoki improves insulin sensitivity via Akt and AMPK activation in 3T3-L1 adipocytes. Fitoterapia. 2016 Jul;112:90-6.|[2]Jae-Ha Ryu, et al. Fitoterapia. 2003 Jun;74 (4) :350-4.Inhibition of nitric oxide production on LPS-activated macrophages by kazinol B from Broussonetia kazinoki.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AMPK

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