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XIAP Antibody

CAT: 0800-RQ7315Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ7315Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
XIAP, also known as IAP3 or BIRC4, is a protein that stops apoptotic cell death. It is mapped to chromosome Xq25. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
P98170
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant human protein (amino acids A15-V244) was used as the immunogen for the XIAP antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
3G2G1
Applications
WB
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the XIAP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This XIAP antibody is available for research use only.
Storage Conditions
After reconstitution, the XIAP antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the XIAP antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) human HeLa, 2) human MCF7, 3) human PANC-1, 4) human U-87 MG, 5) rat heart, 6) rat testis, 7) mouse heart and 8) mouse testis tissue lysate with XIAP antibody. Expected molecular weight ~57 kDa.

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