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APOBEC3B Antibody / A3B

CAT: 0800-RQ7298Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ7298Size:100 µg
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Description
Probable DNA dC->dU-editing enzyme APOBEC-3B is a protein that in humans is encoded by the APOBEC3B gene. This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. A hybrid gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3B, and the adjacent gene APOBEC3A. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B. Two transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q9UH17
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids FNNDPLVLRRRQTYLCYEVER were used as the immunogen for the APOBEC3B antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the APOBEC3B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This APOBEC3B antibody is available for research use only.
Storage Conditions
After reconstitution, the APOBEC3B antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the APOBEC3B antibody should be determined by the researcher.
Image Legend
Western blot testing of human 1) HepG2, 2) Jurkat, 3) ThP-1 and 4) HEK293 cell lysate with APOBEC3B antibody. Predicted molecular weight ~46 kDa, but commonly observed at 35-46 kDa.

UniProtKB · Q9UH17

DNA dC->dU-editing enzyme APOBEC-3B

ABC3B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UH17
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
APOBEC3B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
A3B
EC number
3.5.4.38
Processing
—
Secondary accessions
B0QYD2, O95618, Q20WL1, Q5IFJ4, Q7Z2N3, Q7Z6D6, Q9UE74
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Antiviral defenseImmunityInnate immunity

Molecular function

HydrolaseRNA-binding

Ligand

Metal-bindingZinc

Cellular component

Nucleus

Domain

Repeat
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